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Research
 
RSDSA Research Grant Application

The RSDSA Pain Research Fund supports clinical and basic research activities. The purpose of the Fund is to facilitate the completion of relevant research that will improve our understanding of the epidemiology, natural history, pathophysiology, pathomechanics, diagnosis and treatment of RSD/CRPS-1.

RSDSA Research Granting Cycle

Research Grants are funded from July 1 through June 30 of each calendar year. The deadline for submission of a Research Grant Application is November 1 of the previous calendar year. The final decision on Research Grant funding is made by the RSDSA Board of Directors at its December meeting (generally the first week in each December). Applicants are notified of the Board's decision within 5 business days.

Periodically, RSDSA is asked to support a very promising research initiative that does not adhere to this solicitation and review timetable. The Chairman of the RSDSA Scientific Advisory Committee, at his discretion, convenes the Scientific Advisory Committee or an ad hoc committee to review such a Research Grant Application and advises the Board of Directors on the suitability of funding the proposed research.

Research Grant Application Submission

Mail

RSDSA - Research Grant Application
99 Cherry Street Milford, CT 06460
(203) 877-3790

  If printed on 8 ½ x 11 paper, include three copies.
  As a MSWord document on a CD-ROM.
E-mail as an attachment in MSWord, to: info@rsds.org
  Subject heading should read: Research Grant Application.

Research Grant Application Review Process

Research Grant Applications are reviewed by the RSDSA Scientific Advisory Committee, medical professionals and scientists with experience in clinical and basic research. We reserve the right to seek outside technical consultation as necessary. Research Grant Applications are graded for scientific interest, originality, methodology, the qualifications of the principal investigator and the host institution, and the financial proposal. The Chairman of the Scientific Advisory Committee makes funding recommendations to the Board of Directors, whose decisions are final.
RSDSA observes the highest standards of conduct to insure that conflicts of interest do not influence the Research Grant Review process and that the confidentiality of Research Grant Applications is secure.

Basic Requirement for Research Grant Applications

The proposed research will improve our understanding of the epidemiology, natural history, pathophysiology, pathomechanics, diagnosis and/or treatment of RSD/CRPS-I.

The principle investigator is a health science professional with a career interest in the study and/or treatment of painful conditions. Applicants who are residents, fellows and PhD candidates are under the direct sponsorship and supervision of a senior scientist or faculty member.

The Financial Proposal may not exceed US$50,000 per year.

Research Grants are not limited to US citizens or US institutions; however, all funds requested must be in US dollars and will be paid in US dollars. The amount of the Grant will remain fixed even if rates of exchange fluctuate.

We will only fund one year of a multi-year research project at a time. An interim report and new application will be required for the Board of Directors to consider funding each subsequent year of a multi-year research project.

The application is accompanied by the following documents (where applicable):

1. A letter of support from the Department Chair, the Director of Sponsored Projects, the Dean or the Vice President for Research, the Medical Director or an appropriate authority of the host institution.
2. Copies of approved documents from the host institution's Ethics Committee, Institutional Review Board (IRB), or Institutional Animal Care and Use Committee (IACUC).
3. A copy of the proposed Informed Consent Form, if not included in the IRB or Ethics Committee documents.
4. If the applicant is a resident, fellow, or PhD candidate, a letter from the department chair indicating the career development plans of the applicant.
5. The RSDSA Research Grant Application Declaration, signed by all investigators, indicating their commitment:
  a. to acknowledge the support of the RSDSA Pain Research Fund in any presentation or publication of the research results
b. to submit a progress report after six (6) months of the funding period and at the end of the funding period or accompanying a Research Grant Application for continued funding of the research
c. to submit a final report at the conclusion of the research

d. to submit an itemized financial report
e. to present the results of the research at a national or international pain meeting
f. to submit a manuscript of the research report for publication in a peer reviewed journal

g. to scientific integrity by disclosing any conflicts of interest related to the proposed research

The Formatted Research Grant Application

The Research Grant Application consists of three parts:

Face Sheet (one[1] page)
Scientific Proposal (no more than four [4] pages)
  Scientific Proposal Abstract (one [1] page)
Validation of Methods (two [2] pages)
Investigators and Institution Description (one [1] page)
Financial Proposal (one [1] page)

Research Grant Applications that exceed SIX (6) pages in length will not be reviewed.

Style requirements: 1 inch margins. Minimum type font = 11pt.

Page One(1): Face Sheet

The Face Sheet includes applicant information, host institution information and a Research Grant Application check list. Use the form provided.

Scientific Proposal

Page Two(2): Research Proposal Abstract:The Abstract must conform to the following format. Narrative Abstracts will not be reviewed.

Scientific Proposal Abstract Format:
  Summary of Background Data
Purpose
Hypothesis/hypotheses
Study Design
  Study Subjects
Study Sample
Stratification of the Study Sample
  Main Outcome Measures
Methods
Analysis

Compositional Guidelines

Summary of Background Data Include prior research that is relevant to the proposed research. Avoid a lengthy discussion of what is known and what is not known about RSDS/CRPS-1 in general.
Purpose A single phrase, beginning: "to study the effect of….", "to validate the efficacy and safety of…", "to determine (or to measure) the…", etc.
Hypothesis/hypotheses State in one sentence, each, the primary hypothesis of the research and two (2) secondary hypotheses (if any).
Study Design e.g.: "randomized, blinded, placebo controlled clinical trial", "observational cohort study", "controlled trial in an animal model", "case controlled observational study", etc.
Study Subjects The population from which subjects are selected or the animal/laboratory model.
Study Sample List inclusion and exclusion criteria. State the sample size.
Stratification of the Study Sample State how subjects will be assigned to the experimental and control subsamples. State blinding techniques for both subjects and observers.
Main Outcome Measures List all that apply to the hypothesis or hypotheses
Methods Describe the methods of measurement for each outcome variable. This should be a brief summary statement. The details are presented in the Validation of Methods section of the Scientific Proposal. State the anticipated duration of the research along with the minimum period of follow-up observation.
Analysis State how the outcome measures will be analyzed, including the statistical methods to validate or refute the hypothesis or hypotheses. Describe patient safety monitoring and procedures.

Pages Three and Four (3 and 4): Validation of Methods

This section cites specific prior research on the topic of the proposed research and, if necessary, a brief critique of that work. Justify the methods of subject selection or the choice of the animal or laboratory model. Validate by citation or justify the techniques for stratification and blinding. Specific citations validate the methodology for outcome measurement and reference alternative methods that have been rejected for the proposed research. Cite and annotate work by the investigators on the topic of the proposed research.

Page Five (5): Investigators and Institution

A complete curriculum vitae is not required but may be appended to the Research Grant Application. This section gives a brief narrative description of the academic, clinical practice and research experience of the investigators relevant to the proposed research. A description of the host institution includes IRB, Ethics Committee and/or IACUC functions, institutional history of research support, academic and technical support (statistical consultation if a statistician is not among the investigators), facilities, grant administration, etc.

Financial Proposal

Page Six (6): Financial Proposal

Direct Costs
1) Salary support should be itemized as a "percentage of effort" for each funded investigator or technician.
2) Funding for materials and supplies should be itemized on a "per subject" basis.
3) Durable equipment (DE) support is calculated according to the following formula:
  Support = (Cost of DE x [Duration of Study / Expected Life of DE]) x (Study Sample / Total DE Utilization)
e.g.: If the DE costs $1000 (including upkeep and programmed service), with an expected life of 4 years, and if the duration of the study is 1 year, and if the DE will be used for 50 study subjects as well as for 50 non-study subjects; then the request for durable equipment support is: 1000 x 0.25 x 0.5 = $125.
4) If RSDSA is the sole funding source, travel expenses may be requested to support one investigator to report the results of the research at a national or international (North America) professional or scientific meeting.
5) What percent of the total expense of the study is the RSDSA portion?
Indirect Costs
If RSDSA is the sole funding source, indirect costs and overhead may be supported to a maximum of 10% of the total award.

RSDSA Research Grant Application

Declaration

In accordance with the requirements of The RSDSA Research Grant Application, the applicants declare their commitment:
h. to obtain approval of the host institution's Ethics Committee, IRB or IACUC, if approval is not given prior to application
i. to acknowledge the support of the RSDSA Pain Research Fund in any presentation or publication of the research results
j. to submit a progress report after six (6) months of the funding period and at the end of the funding period or accompanying a Research Grant Application for continued funding of the research
k. to submit a final report at the conclusion of the research
l. to submit an itemized financial report
m. to present the results of the research at a national or international pain meeting
n. to submit a manuscript of the research report for publication in a peer reviewed journal

Signatures and Disclosure of Conflicts of Interest

Investigator  

Conflict of Interest

 

 
Signature  
Investigator  

Conflict of Interest

 

 
Signature  
Investigator  

Conflict of Interest

 

 
Signature  

Please print this sheet, fill in the information, and return it to RSDSA.

 

Face Sheet

Type or print clearly

Title
 
Amount Requested (US dollars)  


Applicant Information (Investigator to whom correspondence should be sent)

Name

Tel #1  
Address Tel #2  
     
Fax E-mail  
City/State/Country Zip or postal code  
Institution

Applicant's Signature:

Application Check List: [x] = Included, [o] = Not Applicable

[ ] Scientific Proposal Abstract
[ ] Validation of Methods
[ ] Description of Investigators and Host Institution
[ ] Financial Proposal
[ ] RSDSA Research Grant Application Declaration Form
[ ] Letter of Support from an Appropriate Authority of the Host Institution
[ ] Documentation of Ethics Committee, IRB and/or IACUC Approval
[ ] Informed Consent Form
[ ] Career Development Plan for Fellows, Residents and/or Ph.D. Candidates

For RSDSA Use Only: Date received:
[ ] Approved [ ] Not Approved Date Applicant Notified:

Updated September 13, 2007

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