Imaging Neuroinflammation and Neuropathic Pain

Organizers:
Mark Cooper, PhD, University of Washington
Vince Clark, PhD, University of New Mexico
Erin Milligan, PhD, University of New Mexico

Hyatt Regency Tamaya Resort & Spa
1300 Tuyuna Trail,
Santa Ana Pueblo, New Mexico, USA 87004
Tel: +1 505 867 1234 Fax: +1 505 771 6180
You can find a map on the website below.
http://www.tamaya.hyatt.com/hyatt/hotels/index.jsp

Workshop is by invitation only. Please contact Debra Nelson-Hogan
(Tel: 212.532.4794, Email: dhogan@seersha.com) for registration information.

Bioluminescence imaging of GFAP-dependent transcription in experimental autoimmune encephalomyelitis. Disease was induced in
GFAP-luciferase transgenic reporter mice with myelin peptides emulsified in adjuvant and bioluminescence was recorded in living mice
1 day before, as well as 12 and 35 days after, immunization. Bioluminescence intensity represents a measure of astrocyte activation (an
important component of neuroinflammation), and correlates with disease progression.

imaging neuroinflammation &neuropathetic pain

Basic researchers, clinicians, and biomedical representatives will jointly examine a variety of neuroimaging methods as technical approaches to further investigate neuroinflammation as an etiology for neuropathic pain and associated comorbidities; and accelerate the development of imaging methods and biomarkers, to help with the diagnosis and treatment of neuroinflammatory diseases.

The objectives of the workshop are to develop imaging tools to diagnose neuroinflammation in individuals with neuropathic pain and other neurological disorders; translate pre-clinical neuroinflammation imaging methods into clinical applications; and foster new collaborations between basic researchers, clinicians, biomedical industries, and patient advocacy groups working on neuroinflammatory disorders.

Imaging Neuroinflammation – An Important Advance for Pain Medicine
Talking with Mark Cooper, PhD
By DEBRA NELSON-HOGAN, The Pain Practitioner, Fall 2011

Thursday, October 13
8:00 am	Registration Opens
8:00–9:00 am	Continental Breakfast Meet and Greet Networking Session	Opening Remarks Mark S. Cooper, PhD
9:00 am–12 pm	Medical Education and Outreach (integrated pain curriculum, pain management) (Introduction) Social Dimensions of Pain (40 min + 5 Q&A) Medical Education in Opioids in the Management of Pain (40 min + 5 Q&A) Medical Education – Forming Partnerships with ECHO (40 min + 5 Q&A) National Perspectives in Continuing Medical Education for Pain (25 min + 5 Q&A)	Session Chair: Erin Milligan, PhD University of New Mexico HSC Albuquerque, NM, USA James Giordano, PhD Potomac Institute for Policy Studies, Arlington, VA., USA., and University of Oxford, Oxford, UK Judith Kitzes, MD, MPH University of New Mexico HSC, Albuquerque, NM, USA Joanna Katzman, MD University of New Mexico HSC, Albuquerque, NM, USA Debra Nelson-Hogan Director of Education; American Academy of Pain Management, Sonora, CA, USA
9:50-10:05 am	Break
12:00–1:30 pm	Lunch
1:30–4:00 pm	UNM Neurosciences Center: Goals in Translational Research Clinical Translational Science Award program at UNM: Current and future directions in transforming basic research into clinical practice. (20 min + 5 min Q&A) Developing Partnerships with UNMs Imaging Capabilities at the Clinical Translational Science Center. (20 min + 5 min Q&A) Forming a Neuroinflammation Knowledge Consortium	Session Chair: Erin Milligan, PhD University of New Mexico HSC, Albuquerque, NM, USA Richard Larson, MD, PhD Vice Chancellor for Research at the University of New Mexico HSC, Albuquerque, NM, USA Corey Ford, MD, PhD Associate Dean for Research at the University of New Mexico HSC, Albuquerque, NM, USA Session Chairs: Mark Cooper, PhD University of Washington, Seattle, WA, USA Peter Moskovitz, MD George Washington University, Washington, DC, USA Medical Research Groups, Patient Advocacy Groups, Patient Support Groups (Virginia Ladd, Barby Ingle) (Panel Discussion: 1 hr, 40 min)
6:45–9:00 pm 7:30–8:30 pm	Welcome Reception & Keynote Address Glial and Endothelial Dysregulation of Pain, Opioid Actions & Drugs of Abuse – the Need for Imaging Is Great! (50 min + 10 min Q&A)	Linda Watkins, PhD University of Colorado, Boulder, CO, USA
Friday, October 14
7:00 am	Registration Opens
7:00–8:00 am	Breakfast
8:00–8:30 am	Workshop Overview and Perspectives	Mark Cooper, PhD University of Washington, Seattle, WA, USA
8:30–9:00 am	Neuroimaging, Neuroinflammation, and Neural Information Processing (25 min + 5 Q&A)	Session Chair: Vince Clark, PhD University of New Mexico and MIND Research Network, Albuquerque, NM, USA
9:00–9:30 am	Imaging Pain with fMRI (25 min + 5 Q&A)	David Borsook, MD Harvard University, Boston, MA, USA
9:30–10:00 am	Central Mechanisms of Pain: fMRI Analysis (25 min + 5 Q&A)	Karen Davis, PhD University of Toronto, Toronto, Canada
10:00–10:15 am	Break
10:15–10:45 am 10:45 am– 12:15 pm 12:15 pm– 12:30	Altered Brain Functional Connectivity of Patients with CRPS: a fMRI Study (25 min + 5 Q&A) SPECT and PET Imaging of Neuroinflammation (25 min talks including Q&A) Spinal Inflammation in Neuropathic Pain (25 min + 5 Q&A) SPECT/PET Imaging Probes for Inflammation (25 min +5 Q&A) Next Generation of SPECT/PET Imaging Tools. (25 min +5 Q&A) Temporomandibular Joint Dysfunction and Movement Disorders (25 min +5 Q&A)	Do-Hyung Kang, MD, PhD and Yong-Chul Kim, MD, PhD Seoul National University, Seoul, Korea Session Chair: Erin Milligan, PhD Erin Milligan, PhD University of New Mexico HSC, Albuquerque, NM, USA Jeffrey Norenberg, PhD Professor and Director, Radiopharmaceutical Sciences Program Director, Keck-UNM Small-Animal Imaging Resource College of Pharmacy, Associate Director, New Mexico Center for Isotopes in Medicine, Albuquerque, NM, USA Ralph James, PhD Brookhaven National Laboratory, Upton, NY, USA Terry Lall Hybridyne Imaging Technologies, Inc. Toronto, Canada Anthony Sims, DDS Columbia, MD, USA
12:30–1:45 pm	Lunch and Networking
	Imaging Neuroinflammatory Processes with MRI and Nanoparticles (25 min talks including Q&A)	Session Chair: Alan Koretsky, PhD
1:45–3:15 pm 3:15–4:15 pm	Post-Surgical Inflammatory Neuropathy (25 min + 5 min Q/A each) Imaging Gastrointestinal Function – an Objective Biomarker for Visceral Pain? Tracking Single Cells in the Brain with MRI Novel Radiogands and Molecular Imaging (25 min talks including Q&A) Combining Nanobodies and SPECT for Molecular and Cellular Imaging of Inflammation. (25 min +5 min Q&A) Molecular Imaging and Autoimmunity (25 min + 5 min Q&A)	Nathan Staff, MD, PhD Mayo Clinic, Rochester, MN, USA Penny Gowland, PhD University of Nottingham, UK Alan Koretsky, PhD National Institute of Neurological Disorders and Stroke Bethesda, MD, USA Session Chair: Sandip Biswal, MD Nick Devoogdt, PhD Vrije University Brussel, Brussels, Belgium Sandip Biswal, MD Stanford University, Pao Alto, CA, USA
4:15–4:30 pm	Break
4:30–5:00 pm	Roundtable Discussion: tie together both the morning and afternoon sessions	Moderator: Richard Banati, MD, PhD University of Sydney, Sydney, Australia Elie D. Al-Chaer, MS, PhD, JD University of Arkansas for Medical Sciences, Little Rock, AR, USA Marek Osinski, PhD University of New Mexico, Albuquerque, NM, USA Mera Barr, PhD University of Toronto, Toronto, Canada
5:00–6:00 pm	Imaging Temporal Dynamics of Neuroinflammation	Session Chair: Mike Dailey, PhD University of Iowa, Iowa City, IA, USA
5:00–5:30 pm	Visualizing Neuroinflammation in Bioluminescent Transgenic Animals	Tony Wyss-Coray, PhD Stanford University, Stanford, CA, USA
5:30–6:00 pm	Imaging the Spread of CRPS with Thermography	Philip Getson, DO Drexel University, Philadelphia, PA, USA
6:30–9:30 pm 7:45–8:45 pm	Dinner and Keynote Address Visualizing the Complex Dynamics of Neuropathic Pain (50 min +10 min Q/A	Carl Saab, PhD Brown University, Providence, RI, USA
Saturday, October 15
7:00–8:00 am	Breakfast
8:00–8:30 am	Clinical Applications of Neuroinflammation Imaging	Session Chair: Joshua Prager, MD UCLA, Los Angeles, CA, USA
8:35–10:00 am	Neuropathic Pain: Medical Compensation Issues	Joshua Prager, MD UCLA, Los Angeles, CA, USA
	20 minute talks + Q&A Neuroimaging in HIV and Substance Abuse: Possible Markers of Neuroinflammation Measuring GABAergic Inhibitory Activity with TMS and its Potential Clinical Applications How do Patients with CRPS Define Recovery and What Are Their Priorities of Future Research? Incorporating Neuroinflammation Imaging Methods into Rehabilitation Medicine	Linda Chang, MD University of Hawaii Medical School, Queens Medical Center, Honolulu, HI, USA Mera Barr, PhD University of Toronto, Toronto, Canada Candy McCabe, PhD University of Bath, Bath, England Norman Harden, MD Rehabilitation Institute of Chicago, IL, USA
10:00–10:30 pm	Break
10:30–12:00pm (noon)	Discussion: what needs to be done to translate imaging technologies from lab to clinical research; from clinical research to clinical practice. Click to view the video. a. How can we get Focus Groups to forward clinical applications? b. How do we get the private sector to help advance neuroinflammation imaging technologies, and interface this effort with the clinical community? c. How can the NIH Clinical Translational Science Awards facilitate the delivery of neuroinflammation imaging technologies to the clinical community?	Session Chair: Norman Harden, MD Rehabilitation Institute of Chicago, IL, USA Participants for commentary/discussion: Richard Banati, MD, PhD University Sydney, Australia Srinivasa Raja, MD Johns Hopkins School of Medicine, Baltimore, MD, USA Elliot Krane, MD Stanford University, Stanford, CA, USA Norman Harden, MD Rehabilitation Institute of Chicago, Chicago, IL, USA Elie D. Al-Chaer, MS, PhD, JD University of Arkansas for Medical Sciences, Little Rock, AR, USA Peter Moskovitz, MD George Washington University, Washington, DC, USA Alan Koretsky, PhD National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA Larry Davis, MD New Mexico Health Care System, Albuquerque, NM, USA Don Manning, MD, PhD University of Virginia Health Science Center, Charlottesville, VA. James Giordano, PhD Potomac Institute for Policy Studies, Arlington, VA, USA and University of Oxford, Oxford, UK Carl Saab, PhD Brown University, Providence, RI, USA Roberto Perez, PhD Trauma Related Neuronal Dysfunction (TREND) Knowledge Consortium, VU, University Medical Center Amsterdam, The Netherlands Ralph James, PhD Brookhaven National Laboratory, Upton, NY, USA Terry Lall Hybridyne Imaging Technologies, Inc. Toronto, Canada

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